Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Its effectiveness for treating sexual dysfunction in women has not been demonstrated. Common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare, but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin , as this may result in a severe and potentially fatal drop in blood pressure. Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 , an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. Since becoming available in...
Shortcuts to chapters:
00:01:23 Pulmonary hypertension
00:01:36 Altitude sickness
00:01:49 Adverse effects
00:03:45 Recreational use
00:05:11 Jet lag research
00:06:43 Mechanism of action
00:10:19 Marketing and sales
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Wikipedia link: https://en.wikipedia.org/wiki/Sildenafil
Trials have already established that the famous blue pill’s main ingredient helps those with damaged hearts by boosting blood flow.
But now a new study by the Centre for Cardiac Research at the University of Manchester has shown that cells from a failing heart actually survive for longer when they are given a Viagra-like drug which is normally used to treat impotence in men.